CAR11是致癌基因，CARD11 (caspase recruitment domain 11)编码蛋白是一种细胞质支架蛋白，通过CARD11/BCL10/MALT1（CBM）复合物介导细胞凋亡和NF-ĸB信号传导。蛋白激酶C（PKC）对CAR11的上调，导致该蛋白质的构象变化和CBM复合物的形成，从而通过IĸB激酶激活NF-κB。在小鼠B细胞中，CARD11是一种分子开关，其决定着激活诱导细胞死亡，或增殖和浆细胞分化的发生。CAR11是致癌基因，CBM复合体的组成性激活是B细胞和T细胞恶性肿瘤的共同特征，尤其是在弥漫性大B细胞淋巴瘤中CAD11的获得性功能突变已得到鉴定。

CARD11 (caspase recruitment domain 11) is a cytoplasmic scaffold protein that functions in mediating apoptosis and NF-ĸB signaling via the CARD11/BCL10/MALT1 (CBM) complex. Upregulation of CARD11 by protein kinase C (PKC) leads to a conformational change of the protein and formation of the CBM complex, resulting in activation of NF-ĸB through the IĸB kinase. In mouse B-cells, CARD11 is a molecular switch defining either the occurrence of activation-induced cell death or proliferation and plasmablast differentiation. CARD11 is an oncogene, and constitutive activation of the CBM complex is a common feature of B- and T-cell malignancies, particularly diffuse large B-cell lymphoma where gain-of-function mutations in CARD11 have been identified.

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