BTG1
小结
BTG1是BTG抗增殖因子1，是调节细胞生长和分化的抗增殖基因家族的成员。 该基因的表达在细胞周期的G0 / G1期最高，并且当细胞通过G1进展时下调。 编码的蛋白质与多种核受体相互作用，并作为细胞分化的共激活因子起作用。 研究显示该基因参与B细胞慢性淋巴细胞白血病中的t（8; 12）（q24; q22）染色体易位。
BTG1 is a member of a family of proteins that regulate cell proliferation. BTG1 acts as an adaptor molecule that stimulates the activity of transcription factors including HOXB9 and RARα. In addition, BTG1 regulates the activity of an epigenetic complex containing PRMT1, an arginine methyltransferase. Expression of BTG1 is important for regulation of cell cycle arrest, apoptosis, and cell proliferation in a variety of cellular contexts. Deadenylation of poyl(A) tails on mRNA is also mediated by BTG1 binding to CNOT7, allowing for regulation of mRNA turnover and decay. BTG1 transcriptional control is important for cerebellum and pre-B cell development as demonstrated in murine models. Loss of BTG1 enhances the stem cell renewal capacity of hematopoietic progenitor cells and mediates the upregulation of BCL6, leading to suppression of the tumor suppressor genes TP53 and p19ARF. Somatic BTG1 loss-of-function mutations occur in diffuse large B cell lymphomas (DLBCL) and deletions occur in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and acute lymphoblastic leukemia (ALL), suggesting that BTG1 functions as a tumor suppressor. Secondary mutations in BTG1 have also been identified in patients with chronic lymphocytic leukemia (CLL) treated with the BCL-2 inhibitor venetoclax.