AURKB是一种丝氨酸/苏氨酸激酶，调节有丝分裂细胞周期进程。AURKB蛋白在G2和有丝分裂期间的增殖细胞中表达，并对多个蛋白磷酸化以保持基因组完整性。AURKB有助于在纺锤体装配检查点建立适当的染色体-纺锤体附着，是胞质分裂的关键。在某些癌症中，如肝细胞癌中，AURKB的表达增加，但目前AURKB表达降低的功能影响尚不明确。据报道，AurkB的过度表达促进成纤维细胞的非整倍体，提示其在促进染色体不稳定性方面具有潜在的作用。

AURKB (Aurora Kinase B) is a cell-cycle regulatory serine/threonine kinase that promotes entry into and proper progression through mitosis. AURKB protein is expressed in proliferating cells during G2 and mitosis and phosphorylates multiple proteins to maintain genome integrity. AURKB aids in the establishment of proper chromosome-spindle attachments in the spindle assembly checkpoint and is essential for cytokinesis. Increased AURKB expression is seen in certain cancers, such as hepatocellular carcinomas, but the functional implication of dysregulated AURKB expression has not been established. Forced over-expression of AURKB was reported to promote aneuploidy in fibroblast cells, suggesting a potential role in promoting chromosome instability.

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