AKT3是致癌基因，编码一种丝氨酸/苏氨酸蛋白激酶（细胞内激酶），其是PI3K信号传导途径中的关键下游效应子。AKT3、AKT1和AKT2是AGC激酶家族的成员。活化的AKT参与细胞周期进展和增加细胞的迁移、分化和葡萄糖稳态。当其pleckstrin同源结构域（PHD）从激酶结构域（KD）脱落时，AKT3活化发生，定位于细胞膜，并且其若干关键残基被磷酸化。AKT3在许多癌症中被扩增，包括胶质母细胞瘤，在各种癌症类型中发生突变的频率较低。

The AKT3 protein is a serine/threonine protein kinase that is a downstream effector in the PI3K signaling pathway. AKT3, along with closely related AKT1 and AKT2, are members of the AGC kinase family. Effects of AKT activation include cell cycle progression and increased migration, differentiation and glucose homeostasis. AKT3 activation occurs when its pleckstrin homology domain (PHD) dislodges from the kinase domain (KD), localizes to the cell membrane, and several of its key residues become phosphorylated. AKT3 is an oncogene and is amplified in many cancers, including glioblastoma. 

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